Noninvasive technology for early detection and monitoring of Alzheimer's disease affecting 5.4M Americans. DiamiR develops proprietary noninvasive tests based on analysis of organ-enriched microRNAs in blood for early discovery of Alzheimer’s, other neurodegenerative diseases and cancer. In January 2014, the company announced validation of promising microRNA biomarkers for Mild Cognitive Impairment, an early stage of dementia including Alzheimer’s disease.
Noninvasive technology for early detection and monitoring of Alzheimer's disease affecting 5.4M Americans
Combine advanced diagnostics and proprietary drugs to target ADPKD and p-STAT3 mediated cancers. The company is developing STAT3 inhibitors for ADPKD. These inhibitors also work particularly in reversing cancer cells resistant to chemotherapy. No alternatives currently exist for either condition, and GLG’s protocol can both improve quality of life and extend lifespan by 10-15 years.
Combine advanced diagnostics and proprietary drugs to target ADPKD and p-STAT3 mediated cancers
New antibiotics target life-threatening infections of drug-resistant organisms like Pseudomonas and Acinetobacter. The Company has developed two distinct classes of compounds and a platform technology. Together, these enable Hsiri to use existing generic drugs to develop new antibiotics directed at specific bacteria species (also including Mycobacterium avium). The U.S. market for these antibiotics exceeds $3 billion.
New antibiotics target life-threatening infections of drug-resistant organisms like Pseudomonas and Acinetobacter
Rapidly develop more effective, individualized therapies for people with epilepsy and other neurological disorders. Focusing on genetically-based epilepsies, Intellimedix designs and applies innovative technologies and models to identify new protocols. It repurposes existing drugs and seeks out new compounds that can personalize disease treatment.
Rapidly develop more effective, individualized therapies for people with epilepsy and other neurological disorders
Genomic Expression develops Next Generation diagnostics to guide health professionals to more individually effective patient treatments. Pioneering gene sequencing and unique access to the biological samples of Rx and Dx companies will create a pipeline of Next Generation Diagnostics. Genomic Expression’s hypothesis-free platform will transforms biomarker discovery from a fishing expedition into a math discipline capable of delivering proof of concept of RNA diagnostics in a matter of months.
Develop Next Generation diagnostics to guide health professionals to more individually effective patient treatments
Developing a therapeutic using perillyl alcohol for intranasal treatment of brain-related and respiratory cancers. Currently, drug delivery to the brain and spinal cord requires oral or intravenous administration. In all such systemic approaches, the blood brain barrier significantly hampers efficacy. Nasal brain delivery bypasses this inhibitor with direct, non-invasive access. NeOnc Technologies (NTI) is working in partnership with a pharmaceutical company to conduct a Phase I/II trial on their lead compound NEO100, for patients suffering recurrent, malignant gliomas.
Developing a therapeutic using perillyl alcohol for intranasal treatment of brain-related and respiratory cancers
This proprietary device allows safe, in-office treatment of middle ear infections that affects 28M people in the US every year. 80% of all children under the age of three suffer from this ailment, and current U.S. CPT reimbursement represents a $4 billion domestic opportunity. Worldwide, the potential rises to $40 billion for the disposable component of Entra Tympanic’s EToscope™.
Device allows safe, in-office treatment of middle ear infections that affects 28M people in the US every year
Developing recombinant human Leptin as a therapy for Alzheimer's Disease (AD) and as a preventative for those at risk. The human hormone and protein Leptin has a large number of receptors in the brain’s memory centers. The protein’s levels often decline in AD patients, and their cognitive deterioration correlates strongly with a decrease in Leptin circulation. The protein is neuroprotective, improves cognition and Neurotez expects it to reduce the pathological hallmarks of Alzheimer’s disease – plaques and tangles. Leptin replacement therapy represents a relatively risk-reduced approach to drug development.
Developing a recombinant human Leptin therapy for Alzheimer's Disease and as a preventative for those at risk
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